May 2014: EGDT Revisited

P: In patient’s with evidence of severe sepsis or septic shock

I:  Does protocol based early goal directed therapy (EGDT)

C: Compared to “routine” non protocol based standard of care

O: Favorably impact 60 day patient mortality
 

Rivers E. et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 Nov 8;345(19):1368-77.
Critical Appraisal Answer Key

Yealy DM, & The ProCESS Investigators, A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014 May 1;370(18):1683-93.
Critical Appraisal Answer Key

Wacker C. et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013 May;13(5):426-35
Critical Appraisal Answer Key